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rs1801133
MTHFR
Key enzyme for converting folate to its active methylfolate form
|
MTHFR
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Methylation & Antioxidants
|
—
|
|
rs225014
DIO2
Affects conversion of inactive T4 to active T3 thyroid hormone in brain, pituitary, and peripheral tissues
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DIO2
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Hormones & Circadian Rhythm
|
—
|
|
rs2802292
FOXO3
Longevity-associated intronic enhancer variant with 1.9-fold increased probability of reaching age 95
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FOXO3
|
Biological Aging & Telomeres
|
—
|
|
rs6265
BDNF
Key neurotrophin variant that controls activity-dependent BDNF release, affecting memory consolidation, neuroplasticity, and stress resilience
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BDNF
|
Brain & Cognition
|
—
|
|
rs7903146
TCF7L2
Main type 2 diabetes risk variant - strongly modulated by dietary fat
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TCF7L2
|
Metabolism & Blood Sugar
|
—
|
|
rs10455872
LPA
Intronic variant strongly associated with elevated lipoprotein(a) levels and significantly increased risk of coronary artery disease and aortic valve stenosis
|
LPA
|
Heart & Cardiovascular
|
—
|
|
rs11206244
DIO1
Common variant in the 3' UTR of the DIO1 gene affecting thyroid hormone metabolism and T3/T4 ratio
|
DIO1
|
Hormones & Circadian Rhythm
|
—
|
|
rs1801131
MTHFR
Second MTHFR variant affecting enzyme activity in the regulatory domain
|
MTHFR
|
Methylation & Antioxidants
|
—
|
|
rs9536314
KLOTHO
Longevity-associated variant exhibiting overdominance where heterozygotes show enhanced cognition and lifespan while homozygotes have reduced survival
|
KLOTHO
|
Biological Aging & Telomeres
|
—
|
|
rs11591147
PCSK9
Loss-of-function variant that naturally lowers LDL cholesterol by 15-28% and reduces coronary disease risk by up to 47%
|
PCSK9
|
Heart & Cardiovascular
|
—
|
|
rs1799941
SHBG
Promoter region variant affecting sex hormone-binding globulin levels, with the A allele increasing SHBG by 15-25% and influencing free testosterone and estradiol bioavailability
|
SHBG
|
Hormones & Circadian Rhythm
|
—
|
|
rs1801282
PPARG
Insulin sensitivity - affects how well your cells respond to insulin
|
PPARG
|
Metabolism & Blood Sugar
|
—
|
|
rs2736100
TERT
Common intron 2 variant in the telomerase gene that influences telomere length, with the C allele associated with longer telomeres and increased cancer risk, while the A allele links to shorter telomeres and higher risk of degenerative diseases
|
TERT
|
Biological Aging & Telomeres
|
—
|
|
rs4986790
TLR4
Missense variant in Toll-like receptor 4 reducing bacterial endotoxin recognition and dampening inflammatory responses
|
TLR4
|
Inflammation & Immune Aging
|
—
|
|
rs12696304
TERC
Regulatory variant near the telomerase RNA gene associated with shorter telomeres and accelerated cellular aging
|
TERC
|
Biological Aging & Telomeres
|
—
|
|
rs429358
APOE
Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high saturated fat
|
APOE
|
Brain & Cognition
|
—
|
|
rs700518
CYP19A1
Synonymous variant in aromatase gene affecting estrogen production, bone density, and response to aromatase inhibitors
|
CYP19A1
|
Hormones & Circadian Rhythm
|
—
|
|
rs1800629
TNF
Promoter variant increasing TNF-alpha production approximately 2-fold, associated with autoimmune diseases and anti-TNF drug response
|
TNF
|
Inflammation & Immune Aging
|
—
|
|
rs1801394
MTRR
B12 recycling enzyme — regenerates active B12 for the methylation cycle
|
MTRR
|
Methylation & Antioxidants
|
—
|
|
rs7412
APOE
APOE E2 variant - generally protective for cardiovascular health
|
APOE
|
Brain & Cognition
|
—
|
|
rs7895833
SIRT1
Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and oxidative stress protection
|
SIRT1
|
Biological Aging & Telomeres
|
—
|
|
rs174547
FADS1
Omega-3 fatty acid conversion efficiency - affects ability to make EPA/DHA from plant sources
|
FADS1
|
Metabolism & Blood Sugar
|
—
|
|
rs1805087
MTR
Methionine synthase — uses B12 to convert homocysteine to methionine
|
MTR
|
Methylation & Antioxidants
|
—
|
|
rs2295080
MTOR
Promoter variant that reduces mTOR expression; the G allele lowers mTOR transcriptional activity and is associated with decreased cancer risk across multiple tumor types
|
MTOR
|
Metabolism & Blood Sugar
|
—
|
|
rs5186
AGTR1
3' UTR variant in angiotensin II type 1 receptor affecting blood pressure regulation and ARB drug response
|
AGTR1
|
Heart & Cardiovascular
|
—
|
|
rs2234693
ESR1
Estrogen receptor alpha intron variant affecting receptor expression and estrogen sensitivity
|
ESR1
|
Hormones & Circadian Rhythm
|
—
|
|
rs2476601
PTPN22
The strongest non-HLA autoimmune risk allele, affecting T-cell and B-cell signaling threshold
|
PTPN22
|
Inflammation & Immune Aging
|
—
|
|
rs662
PON1
Affects paraoxonase-1 enzyme activity for detoxifying organophosphates and protecting LDL from oxidation
|
PON1
|
Heart & Cardiovascular
|
—
|
|
rs6721961
NFE2L2
Promoter variant reducing NRF2 transcriptional activity by >50%, impairing the master antioxidant response that controls glutathione synthesis, phase II detoxification, and cytoprotective gene expression
|
NFE2L2
|
Methylation & Antioxidants
|
—
|
|
rs1042522
TP53
p53 codon 72 polymorphism producing two functionally distinct proteins — Arg72 with stronger apoptotic activity, Pro72 favoring cell cycle arrest and DNA repair — with population data associating Pro/Pro with ~3 years longer median lifespan
|
TP53
|
Biological Aging & Telomeres
|
—
|
|
rs1205
CRP
3' UTR variant that modulates baseline C-reactive protein levels and inflammatory status
|
CRP
|
Inflammation & Immune Aging
|
—
|
|
rs1800795
IL6
Promoter variant controlling interleukin-6 expression — affects inflammation, exercise recovery, and cardiovascular risk
|
IL6
|
Inflammation & Immune Aging
|
—
|
|
rs1801260
CLOCK
Core circadian clock transcription factor variant affecting mRNA stability, associated with evening preference, delayed sleep onset, and shorter sleep duration
|
CLOCK
|
Hormones & Circadian Rhythm
|
—
|